Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis <i>via</i> Nrf2 pathway activation-Reference-Cited by-同舟云学术

Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation

Published:2023 Issue:4 Volume:14 Page:1884-1896
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Huiyi¹²³⁴,Weng Qiqing¹²³⁴,Gong Shuai¹²³⁴,Zhang Weixian¹²³⁴,Wang Jiaqi¹²³⁴,Huang Yuqiao¹²³⁴,Li Yuanjun¹²³⁴,Guo Jiao¹²³⁴,Lan Tian¹²³⁴^ORCID

Affiliation:

1. Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, 280 Wai Huan Dong Road, Guangzhou 510006, China

2. Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China

3. Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China

4. Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China

Abstract

Kaempferol binds to Keap1, leading to the release of Nrf2 and activation of the Nrf2 pathway, which enhance antioxidant and anti-inflammatory effects, inhibit hepatocyte ferroptosis, and alleviate APAP-induced liver injury.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO02716J

Reference75 articles.

1. Acetaminophen-related Hepatotoxicity

2. Acetaminophen Hepatotoxicity