A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells-Reference-Cited by-同舟云学术

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Published:2015 Issue:2 Volume:51 Page:413-416
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hakata Y.¹²³⁴⁵,Tsuchiya S.⁶⁷⁸⁵,Michiue H.⁹¹⁰¹¹¹²¹³,Ohtsuki T.¹⁴¹⁵¹²¹⁶⁵,Matsui H.⁹¹⁰¹¹¹²¹³,Miyazawa M.¹²³⁴⁵,Kitamatsu M.⁶⁷⁸⁵

Affiliation:

1. Department of Immunology

2. Faculty of Medicine

3. Kinki University

4. Osaka 589-8511

5. Japan

6. Department of Applied Chemistry

7. Faculty of Science and Engineering Kinki University

8. Osaka 577-8502

9. Department of Physiology

10. Graduate School of Medicine

11. Dentistry and Pharmaceutical Sciences

12. Okayama University

13. Okayama 700-8558

14. Department of Biotechnology

15. Graduate School of Natural Science and Technology

16. Okayama 700-8530

Abstract

We delivered a hybrid of an autophagy-inducing peptide and a cell-penetrating peptide via heterodimeric leucine zippers into the cell. By this method, the peptide successfully induced autophagy without significant cell death.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC07459A

Reference11 articles.

1. Membrane-permeable arginine-rich peptides and the translocation mechanisms

2. A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

3. In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

4. Cellular Uptake of Arginine-Rich Peptides: Roles for Macropinocytosis and Actin Rearrangement

5. A protein transduction method using oligo-arginine (3R) for the delivery of transcription factors into cell nuclei

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Covalent conjugation and non-covalent complexation strategies for intracellular delivery of proteins using cell-penetrating peptides;Biomedicine & Pharmacotherapy;2024-07

2. Selective Self-assembly of Gold Nanocrystals Using Complementary Leucine Zipper Peptides;Chemistry Letters;2023-10-06

3. Adjusting Heterodimeric Coiled-Coils (K/E Zipper) to Connect Autophagy-Inducing Peptide with Cell-Penetrating Peptide;Pharmaceutics;2023-03-24

4. Protein Delivery and Mimicry;CPP, Cell-Penetrating Peptides;2023

5. Cell-Translocation Mechanisms of CPPs;CPP, Cell-Penetrating Peptides;2023