A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: <i>in vitro</i>/<i>in vivo</i> experimental evaluation for the treatment of corneal alkali burns-Reference-Cited by-同舟云学术

A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns

Published:2023 Issue:7 Volume:11 Page:2531-2542
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Sun Zongjian¹²,Zhang Mingxin¹,Wei Yanjun³,Li Mengshuang⁴,Wu Xianggen¹^ORCID,Xin Meng¹²

Affiliation:

1. College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

2. Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China

3. Viwit Pharmaceutical Co., Ltd. Zaozhuang, Shandong, China

4. Qingdao Women and Children's Hospital, Qingdao, China

Abstract

A simple but novel ophthalmic solution based on two approved drugs (empagliflozin and glycyrrhizin) was developed with a significant effect against corneal alkali burns in mice involving the mechanism of inhibiting HMGB1 signaling.

Funder

Peking University People's Hospital

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01957D

Reference36 articles.

1. Treatment of acute ocular chemical burns

2. Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes