Synthesis of 1,2,3-triazole-piperazin-benzo[<i>b</i>][1,4]thiazine 1,1-dioxides: antibacterial, hemolytic and <i>in silico</i> TLR4 protein inhibitory activities-Reference-Cited by-同舟云学术

Synthesis of 1,2,3-triazole-piperazin-benzo[b][1,4]thiazine 1,1-dioxides: antibacterial, hemolytic and in silico TLR4 protein inhibitory activities

Published:2024 Issue:13 Volume:14 Page:8921-8931
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ramu Nagavelli¹,Krishna Thupurani Murali²,Kapavarapu Ravikumar³,Narsimha Sirassu¹^ORCID

Affiliation:

1. Department of Chemistry, Chaitanya Deemed to be University, Hyderabad, Telangana, India

2. Department of Biotechnology, Chaitanya Deemed to be University, Hyderabad, Telangana, India

3. Department of Pharmaceutical Chemistry and Phytochemistry, Nirmala College of Pharmacy, Atmakur, Mangalgiri, Andhra Pradesh, India

Abstract

Novel 1,2,3-triazoles (6a–6j & 8a–8g) were synthesized and evaluated for their antibacterial activity against S. aureus. The more potent compounds were further evaluated for their in silico TLR4 inhibitory activity.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA07509E

Reference40 articles.

1. N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria

2. Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?

3. The Hemolyzed Sample: To Analyse Or Not To Analyse

4. Managing hemolyzed samples in clinical laboratories

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