Phycocyanobilin, a bioactive tetrapyrrolic compound of blue-green alga Spirulina, binds with high affinity and competes with bilirubin for binding on human serum albumin-Reference-Cited by-同舟云学术

Phycocyanobilin, a bioactive tetrapyrrolic compound of blue-green alga Spirulina, binds with high affinity and competes with bilirubin for binding on human serum albumin

Published:2015 Issue:76 Volume:5 Page:61787-61798
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Minic Simeon L.¹²³⁴⁵,Milcic Miloš¹²³⁴⁵,Stanic-Vucinic Dragana¹²³⁴⁵,Radibratovic Milica⁶⁷⁴⁵⁸,Sotiroudis Theodore G.⁹¹⁰¹¹¹²¹³,Nikolic Milan R.¹²³⁴⁵,Velickovic Tanja Ćirković¹²³⁴⁵

Affiliation:

1. Department of Biochemistry

2. Center of Excellence for Molecular Food Sciences

3. Faculty of Chemistry

4. University of Belgrade

5. 11000 Belgrade

6. Institute of Chemistry

7. Technology and Metallurgy – Center for Chemistry

8. Serbia

9. Institute of Biology

10. Medicinal Chemistry and Biotechnology

11. National Hellenic Research Foundation

12. 11635 Athens

13. Greece

Abstract

High affinity, stereo-selective binding of phycocyanobilinM-conformer to HSA, and its competition with bilirubin, warfarin and hemin for the binding to protein.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA05534B

Reference50 articles.

1. Nutraceutical properties of phycocyanin

2. Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats

3. Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds

4. Subdomain IB Is the Third Major Drug Binding Region of Human Serum Albumin: Toward the Three-Sites Model

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