Dual-core-component multiphasic bioceramic granules with selective-area porous structures facilitating bone tissue regeneration and repair

Author:

Cao Binji1,Xie Lijun1,Xu Yan2,Shen Jian3,Zhang Yan2,Wang Yingjie4,Weng Xisheng4,Bao Zhaonan2,Yang Xianyan2,Gou Zhongru2,Wang Cong1ORCID

Affiliation:

1. Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, #88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China

2. Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China

3. Department of Emergency Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine and Institute of Emergency Medicine, #88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China

4. Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China

Abstract

Ca-phosphate/-silicate ceramic granules have been widely studied because their abilities of biodegradable, bioactive ion release and material degradation; however, it is difficult to synergise time-dependent ion release and highly efficient osteogenesis in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Basic Public Welfare Research Program of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

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