Transmembrane oligomeric intermediates of pore forming toxin Cytolysin A determine leakage kinetics
Author:
Affiliation:
1. Department of Chemical Engineering
2. Indian Institute of Science
3. Bangalore-560012
4. India
5. Indian Institute of Technology
6. Hyderabad-502205
7. Centre for Biosystems Science and Engineering
Abstract
Leakage kinetics of Cytolysin A, an α pore forming toxin, occurs through stochastic insertion of oligomeric intermediates or ‘arcs’.
Funder
Department of Science and Technology, Ministry of Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA07304F
Reference34 articles.
1. An Engineered ClyA Nanopore Detects Folded Target Proteins by Selective External Association and Pore Entry
2. Assembly and Topography of the Prepore Complex in Cholesterol-dependent Cytolysins
3. Vertical collapse of a cytolysin prepore moves its transmembrane β-hairpins to the membrane
4. Visualization of Lipid Membrane Reorganization Induced by a Pore-Forming Toxin Using High-Speed Atomic Force Microscopy
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