Total synthesis of lamellarin G trimethyl ether through enaminone cyclocondensation

Author:

Šachlevičiūtė Urtė12ORCID,Kleizienė Neringa1ORCID,Bieliauskas Aurimas1ORCID,Šačkus Algirdas1,Opatz Till2ORCID

Affiliation:

1. Institute of Synthetic Chemistry, Kaunas University of Technology, K. Baršausko g. 59, LT-51423 Kaunas, Lithuania

2. Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany

Abstract

A synthesis of pyrrolo[2,1-a]isoquinolines based on intramolecular condensation of an enaminone intermediate obtained by C-acylation of an N-alkylated 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolinium salt was developed.

Funder

Directorate-General XII, Science, Research, and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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