A highly diastereoselective Friedel–Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles-Reference-Cited by-同舟云学术

A highly diastereoselective Friedel–Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles

Published:2015 Issue:11 Volume:13 Page:3363-3370
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Jian-Ping¹²³⁴⁵,Chen Wen-Wen¹²³⁴⁵,Li Yi¹²³⁴⁵,Xu Ming-Hua¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Drug Research

2. Shanghai Institute of Materia Medica

3. Chinese Academy of Sciences

4. Shanghai 201203

5. China

Abstract

A Lewis acid promoted highly diastereoselective asymmetric Friedel–Crafts alkylation of indoles with isatin-derived N-tert-butanesulfinyl ketimines is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00063G

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