Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3-Reference-Cited by-同舟云学术

Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3

Published:2019 Issue:41 Volume:9 Page:23484-23497
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Freichel Tanja¹²³⁴,Laaf Dominic⁵⁶⁷⁸⁹,Hoffmann Miriam¹²³⁴,Konietzny Patrick B.¹²³⁴,Heine Viktoria⁵⁶⁷⁸⁹,Wawrzinek Robert¹⁰¹¹⁴,Rademacher Christoph¹⁰¹¹⁴^ORCID,Snyder Nicole L.¹²¹³¹⁴^ORCID,Elling Lothar⁵⁶⁷⁸⁹^ORCID,Hartmann Laura¹²³⁴^ORCID

Affiliation:

1. Department of Organic and Macromolecular Chemistry

2. Heinrich-Heine-University Düsseldorf

3. 40225 Düsseldorf

4. Germany

5. Laboratory for Biomaterials

6. Institute for Biotechnology

7. Helmholtz-Institute for Biomedical Engineering

8. RWTH Aachen University

9. 52074 Aachen

10. Max Planck Institute of Colloids and Interfaces

11. 14424 Potsdam

12. Department of Chemistry

13. Davidson College

14. USA

Abstract

We combine multivalent presentation of glycan ligands on sequence-defined oligo(amidoamines) and liposomes to achieve high avidity ligands targeting galectin-3.

Funder

Deutsche Forschungsgemeinschaft

Boehringer Ingelheim Stiftung

Heinrich-Heine-Universität Düsseldorf

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA05497A

Reference92 articles.

1. Glycans in cancer and inflammation — potential for therapeutics and diagnostics