Transition-metal-free radical difluorobenzylation/cyclization of unactivated alkenes: access to ArCF<sub>2</sub>-substituted ring-fused quinazolinones-Reference-Cited by-同舟云学术

Transition-metal-free radical difluorobenzylation/cyclization of unactivated alkenes: access to ArCF₂-substituted ring-fused quinazolinones

Published:2022 Issue:48 Volume:20 Page:9722-9733
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yuan Jin-Wei¹^ORCID,Zhang Mei-Yue¹,Liu Yan¹,Hu Wen-Yu¹,Yang Liang-Ru¹^ORCID,Xiao Yong-Mei¹,Diao Xiao-Qiong¹,Zhang Shou-Ren²^ORCID,Mao Jian³

Affiliation:

1. School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China

2. Henan Key Laboratory of Nanocomposites and Applications, Institute of Nanostructured Functional Materials, Huanghe Science and Technology College, Zhengzhou 450006, China

3. Zhengzhou Tobacco Research Institute of China National Tobacco Company, Zhengzhou 450001, P. R. China

Abstract

A mild and efficient transition metal-free radical difluoroarylmethylation/cyclization of unactivated alkenes toward the synthesis of quinazolinone derivatives with easily accessible α,α-difluoroarylacetic acids has been developed.

Funder

Henan University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01904C

Reference80 articles.

1. 4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

2. Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

3. Quinoline, quinazoline and acridonealkaloids