Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis

Author:

Zhan Zi-Ying12,Zhang Zhi-Hong12,Yang Hong-Xu12,Wu Yan-Ling123,Nan Ji-Xing123ORCID,Lian Li-Hua123ORCID

Affiliation:

1. Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University) of State Ethnic Affairs Commission, College of Pharmacy, Yanbian, University, Yanji, Jilin Province 133002, China

2. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China

3. Interdisciplinary of Biological Functional Molecules, College of Integration Science, Yanbian University, Yanji, Jilin Province 133002, China

Abstract

Cos improved psoriasis-like lesions caused by imiquimod stimulation, and might have a therapeutic effect on skin inflammation through P2X7R/IL-36 related pathways.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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