Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications

Author:

Kleczewska Natalia1234ORCID,Sikorski Pawel J.1234,Warminska Zofia12345,Markiewicz Lukasz1234,Kasprzyk Renata12345ORCID,Baran Natalia12346,Kwapiszewska Karina784ORCID,Karpinska Aneta784ORCID,Michalski Jaroslaw784,Holyst Robert784,Kowalska Joanna910114ORCID,Jemielity Jacek1234ORCID

Affiliation:

1. Centre of New Technologies

2. University of Warsaw Banacha 2c

3. 02-097 Warsaw

4. Poland

5. College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences

6. Faculty of Biology University of Warsaw

7. Institute of Physical Chemistry Polish Academy of Sciences

8. 01-224 Warsaw

9. Division of Biophysics Institute of Experimental Physics

10. Faculty of Physics University of Warsaw

11. 02-093 Warsaw

Abstract

Ligand assisted cellular delivery of negatively charged dinucleotides, which are potential antagonists of the protooncogenic protein eIF4E.

Funder

Narodowym Centrum Nauki

Fundacja na rzecz Nauki Polskiej

Narodowe Centrum Badań i Rozwoju

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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