High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis-Reference-Cited by-同舟云学术

High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis

Published:2017 Issue:9 Volume:53 Page:1506-1509
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Jiang Haibo¹²³⁴⁵,Passarelli Melissa K.⁶⁷⁸⁹,Munro Peter M. G.¹⁰¹¹⁹,Kilburn Matt R.¹²³⁴⁵,West Andrew¹²¹³⁹,Dollery Colin T.¹²¹³⁹,Gilmore Ian S.⁶⁷⁸⁹,Rakowska Paulina D.⁶⁷⁸⁹

Affiliation:

1. Centre for Microscopy

2. Characterisation and Analysis

3. University of Western Australia

4. Crawley

5. Australia

6. National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI)

7. National Physical Laboratory

8. Teddington

9. UK

10. Institute of Ophthalmology

11. University College London

12. GlaxoSmithKline

13. Stevenage

Abstract

Correlative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC08549K

Reference34 articles.

1. Intravenous Amiodarone: Pharmacology, Pharmacokinetics, and Clinical use

2. Very Early Onset of Amiodarone-Induced Pulmonary Toxicity

3. Drug-induced phospholipidosis

4. U. M. Hanumegowda and A.Regueiro-Ren, in Tactics in Contemporary Drug Design, ed. A. N. Meanwell, Springer, Berlin, Heidelberg, 2015, pp. 261–281

5. N. Sadrieh , Presented in part at the FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology meeting, April 2010

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