Aβ under stress: the effects of acidosis, Cu2+-binding, and oxidation on amyloid β-peptide dimers-Reference-Cited by-同舟云学术

Aβ under stress: the effects of acidosis, Cu2+-binding, and oxidation on amyloid β-peptide dimers

Published:2018 Issue:56 Volume:54 Page:7766-7769
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liao Qinghua¹²³⁴⁵^ORCID,Owen Michael C.¹²³⁶⁷,Bali Sofia¹²³⁸⁹,Barz Bogdan¹²³¹⁰¹¹^ORCID,Strodel Birgit¹²³¹⁰¹¹^ORCID

Affiliation:

1. Institute of Complex Systems, Structural Biochemistry (ICS-6)

2. 52425 Jülich

3. Germany

4. Science for Life Laboratory

5. Department of Cell and Molecular Biology

6. CEITEC – Central European Institute of Technology

7. Masaryk University

8. New Mexico State University

9. Las Cruces

10. Institute of Theoretical and Computational Chemistry

11. Heinrich Heine University Düsseldorf

Abstract

In light of the high affinity of Cu²⁺ for Alzheimer's Aβ_1–42 and its ability to subsequently catalyze the formation of radicals, we examine the effects of Cu²⁺ binding, Aβ oxidation, and an acidic environment on the conformational dynamics of the smallest Aβ_1–42 oligomer, the Aβ_1–42 dimer.

Funder

China Scholarship Council

Helmholtz Association

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC02263A

Reference37 articles.

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5. Cu2+ Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces

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