Targeting G-quadruplex DNA with synthetic dendritic peptide: modulation of the proliferation of human cancer cells
Author:
Affiliation:
1. Department of Biochemistry and Biophysics
2. University of Kalyani
3. Nadia
4. India
5. Department of Chemistry
6. Indian Institute of Technology Indore
7. Indore 453552
8. Department of Biochemistry
9. Indian Institute of Science
10. Bangalore
Abstract
A synthetic dendritic peptide, targeting human telomeric G4 DNA, inhibits the telomerase and lessens the proliferation of human cancer cells.
Funder
University of Kalyani
Department of Biotechnology, Government of West Bengal
Council of Scientific and Industrial Research, India
University Grants Commission
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA04780E
Reference52 articles.
1. DNA secondary structures: stability and function of G-quadruplex structures
2. Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
3. Structural insights into G-quadruplexes: towards new anticancer drugs
4. Telomere Dysfunction Increases Mutation Rate and Genomic Instability
5. Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
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1. Peptides and Peptide Derivatives as G‐Quadruplex Targeting Ligands: A Brief Review;ChemistrySelect;2023-09-07
2. Why to target G‐quadruplexes using peptides: Next‐generation G4‐interacting ligands;Journal of Peptide Science;2023-04-25
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4. Understanding the Interactions of Guanine Quadruplexes with Peptides as Novel Strategies for Diagnosis or Tuning Biological Functions;ChemBioChem;2023-02-02
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