Enhanced dissolution and oral bioavailability of lurasidone hydrochloride nanosuspensions prepared by antisolvent precipitation–ultrasonication method-Reference-Cited by-同舟云学术

Enhanced dissolution and oral bioavailability of lurasidone hydrochloride nanosuspensions prepared by antisolvent precipitation–ultrasonication method

Published:2016 Issue:54 Volume:6 Page:49052-49059
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lu Shan¹²³⁴,Yu Pan-pan¹²³⁴,He Jian-Hua¹²³⁴,Zhang Shuang-shuang¹²³⁴,Xia Yu-Long¹²³⁴,Zhang Wen-Li¹²³⁴,Liu Jian-Ping¹²³⁴

Affiliation:

1. Department of Pharmaceutics

2. China Pharmaceutical University

3. Nanjing 210009

4. People's Republic of China

Abstract

Lurasidone hydrochloride nanosuspensions exhibited a significant improvement in the bioavailability, which was correlated with the increased solubility and in vitro dissolution resulting from the smaller particle size of lurasidone hydrochloride.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA08392G

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