The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with l-valine alkyl esters

Author:

Ossowicz Paula12345ORCID,Klebeko Joanna12345ORCID,Janus Ewa12345ORCID,Nowak Anna6785ORCID,Duchnik Wiktoria6785ORCID,Kucharski Łukasz6785ORCID,Klimowicz Adam6785ORCID

Affiliation:

1. West Pomeranian University of Technology, Szczecin

2. Faculty of Chemical Technology and Engineering

3. Department of Chemical Organic Technology and Polymeric Materials

4. 71-065 Szczecin

5. Poland

6. Pomeranian Medical University in Szczecin

7. Department of Cosmetic and Pharmaceutical Chemistry

8. 70-111 Szczecin

Abstract

The effect of various alcohols as vehicles on skin permeability was compared for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with l-valine alkyl esters [ValOR][IBU], in which the alkyl chain R was changed from C1 to C8.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference70 articles.

1. Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

2. H. A. E.Benson , in Topical and Transdermal Drug Delivery , ed. H. A. E. Benson and A. C. Watkinson , John Wiley & Sons, Inc. , Hoboken, NJ, USA , 2012 , pp. 1–22

3. M. E.Lane , P.Santos , A. C.Watkinson and J.Hadgraft , in Topical and Transdermal Drug Delivery , ed. H. A. E. Benson and A. C. Watkinson , John Wiley & Sons, Inc. , Hoboken, NJ, USA , 2012 , pp. 23–42

4. N.Dragicevic , J. P.Atkinson and H. I.Maibach , in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum , ed. N. Dragicevic and H. I. Maibach , Springer Berlin Heidelberg , Berlin, Heidelberg , 2015 , pp. 11–27

5. C. M.Heard , in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement , ed. N. Dragicevic and H. I. Maibach , Springer Berlin Heidelberg , Berlin, Heidelberg , 2015 , pp. 151–172

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