Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction-Reference-Cited by-同舟云学术

Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction

Published:2016 Issue:44 Volume:14 Page:10357-10361
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chi Yongjian¹²³⁴⁵,Qiu Lihua¹²³⁴⁵,Xu Xinfang¹²³⁴⁵

Affiliation:

1. Key Laboratory of Organic Synthesis of Jiangsu Province; College of Chemistry

2. Chemical Engineering and Materials Science

3. Soochow University

4. Suzhou 215123

5. P. R. China

Abstract

An asymmetric cyclopropanation reaction of N-Boc diazooxindoles is described with good to excellent enantioselectivities, especially with alkyl alkenes (>90% ee).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB02160C

Reference86 articles.

1. Therapeutic Potential of Spirooxindoles as Antiviral Agents

2. Spirooxindoles: Promising scaffolds for anticancer agents

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4. Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

5. Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

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