Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria
Author:
Affiliation:
1. Department Microbial Natural Products
2. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)
3. Helmholtz Centre for Infection Research (HZI)
4. Department of Pharmaceutical Biotechnology
5. Saarland University
Abstract
Mining the genome to harvest from the metabolome: a well-directed search for bioactive natural products unearths the pyxidicyclines fromPyxidicoccus.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC01325J
Reference50 articles.
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4. Detection of metabolite induction in fungal co-cultures on solid media by high-throughput differential ultra-high pressure liquid chromatography–time-of-flight mass spectrometry fingerprinting
5. Biosynthesis and Structures of Cyclomarins and Cyclomarazines, Prenylated Cyclic Peptides of Marine Actinobacterial Origin
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