Anticancer potential of NSAID-derived tris(pyrazolyl)methane ligands in iron(<scp>ii</scp>) sandwich complexes-Reference-Cited by-同舟云学术

Anticancer potential of NSAID-derived tris(pyrazolyl)methane ligands in iron(ii) sandwich complexes

Published:2024 Issue:32 Volume:53 Page:13503-13514
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Gobbo Alberto¹^ORCID,Pereira Sarah A. P.²³,Mota Fátima A. R.²,Sinenko Irina³,Glinkina Kseniya³,Rocchi Dario¹,Guelfi Massimo¹,Biver Tarita¹^ORCID,Donati Chiara⁴,Zacchini Stefano⁵^ORCID,Saraiva M. Lúcia M. F. S.²^ORCID,Dyson Paul J.³^ORCID,Marchetti Fabio¹^ORCID

Affiliation:

1. University of Pisa, Department of Chemistry and Industrial Chemistry, Via G. Moruzzi 13, I-56124 Pisa, Italy

2. LAQV, REQUIMTE, Laboratório de Química Aplicada, Faculdade de Farmácia da Universidade do Porto, Portugal

3. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH 1015, Switzerland

4. University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Via F. Marzolo 5, I-35131 Padova, Italy

5. University of Bologna, Department of Industrial Chemistry “Toso Montanari”, Via P. Gobetti 85, I-40129 Bologna, Italy

Abstract

Flurbiprofen and ibuprofen have been tethered to the skeleton of tris(pyrazolyl)methane, the resulting iron(II) complexes displaying antiproliferative activity and enzyme inhibition capacity largely influenced by the bioactive fragment.

Funder

Università di Pisa

Fundação para a Ciência e a Tecnologia

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT00920G

Reference83 articles.

1. Metallodrugs are unique: opportunities and challenges of discovery and development

2. A survey of the mechanisms of action of anticancer transition metal complexes

3. Classification of Metal-Based Drugs according to Their Mechanisms of Action

4. Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

5. Cisplatin: The first metal based anticancer drug