Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry-Reference-Cited by-同舟云学术

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

Published:2015 Issue:1 Volume:13 Page:269-276
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Radzikowska Ewa¹²³⁴⁵,Baraniak Janina¹²³⁴⁵

Affiliation:

1. Department of Bioorganic Chemistry

2. Center of Molecular and Macromolecular Studies

3. Polish Academy of Sciences

4. 90-363 Łódź

5. Poland

Abstract

Chimeric oligonucleotides containing stereoregular phosphorothioate and natural phosphodiester linkages have been obtained on the solid phase support using nucleoside oxathiaphospholanes and commercially available nucleoside phosphoramidites.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01837K

Reference58 articles.

1. The Role of Environmental Carcinogens, Viruses, and Genetic

2. RNA therapeutics: beyond RNA interference and antisense oligonucleotides

3. Antisense oligonucleotides: towards clinical trials

4. Developing antisense oligonucleotides from the laboratory to clinical trials

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