The morphological role of ligand inhibitors in blocking receptor- and clathrin-mediated endocytosis-Reference-Cited by-同舟云学术

The morphological role of ligand inhibitors in blocking receptor- and clathrin-mediated endocytosis

Published:2022 Issue:18 Volume:18 Page:3531-3545
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Agostinelli Daniele¹²^ORCID,Elfring Gwynn J.¹²,Bacca Mattia¹²³^ORCID

Affiliation:

1. Mechanical Engineering Department, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

2. Institute of Applied Mathematics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

3. School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

Abstract

Particles that enter cells through receptor- and clathrin-mediated endocytosis can be blocked by the presence of sufficiently large and numerous ligand inhibitors, as dictated by mechanical constraints.

Funder

Michael Smith Foundation for Health Research

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SM/D1SM01710A

Reference69 articles.

1. Physical Principles of Nanoparticle Cellular Endocytosis

2. Cellular uptake of nanoparticles: journey inside the cell

3. Spontaneous-Curvature Theory of Clathrin-Coated Membranes

4. The effect of particle design on cellular internalization pathways

5. Strategies in the design of nanoparticles for therapeutic applications

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