Role of tryptophan 135 of Chandipura virus phosphoprotein P in dimerization and complex formation with leader RNA: structural aspect using time resolved anisotropy and simulation-Reference-Cited by-同舟云学术

Role of tryptophan 135 of Chandipura virus phosphoprotein P in dimerization and complex formation with leader RNA: structural aspect using time resolved anisotropy and simulation

Published:2015 Issue:126 Volume:5 Page:104582-104593
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mukherjee Manini¹²³⁴,Sarkar Aditya⁵⁶⁷⁸⁴,Roy Arunava⁹¹⁰⁷¹¹⁴,Sardar Pinki Saha¹²³⁴,Lahiri Ansuman⁵⁶⁷⁸⁴,Chattopadhyay Dhrubajyoti⁹¹⁰⁷¹¹⁴,Ghosh Sanjib¹²³⁴

Affiliation:

1. Department of Chemistry

2. Presidency University

3. Kolkata 700 073

4. India

5. Department of Bio-Physics

6. Molecular Biology and Bioinformatics

7. University of Calcutta

8. Kolkata-700 009

9. Dr B. C. Guha Centre for Generic Engineering and Biotechnology

10. Department of Biotechnology

11. Kolkata 700019

Abstract

The nanosecond and picosecond dynamics of wild type protein and its tryptophan mutants have been used to study structural change as a function of protein concentration and binding with leader RNA by time resolved anisotropy and molecular dynamics.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA20863G

Reference31 articles.

1. Sequences of chandipura virus N and NS genes: Evidence for high mutability of the NS gene within vesiculoviruses

2. Reviewing Chandipura: A Vesiculovirus in Human Epidemics

3. P-Protein of Chandipura Virus Is an N-Protein-Specific Chaperone That Acts at the Nucleation Stage

4. Role of the Hypervariable Hinge Region of Phosphoprotein P of Vesicular Stomatitis Virus in Viral RNA Synthesis and Assembly of Infectious Virus Particles

5. Monomer and Dimer of Chandipura Virus Unphosphorylated P-protein Binds Leader RNA Differently: Implications for Viral RNA Synthesis