A nanostructured lateral flow immunoassay strip combined with Au@SiO2 SERS nanotags for multiplex biomarker detection

Author:

Zhu Geng123,Zhan Yuanbao123,Lu Yu123,Zheng Fei4ORCID,Wan Yu15,Liu Bing6,Yang Xi123,Wan Yanhui7,Sun Qingjiang1ORCID,Sha Jingjie4,Huang Yan123,Zhao Xiangwei123ORCID

Affiliation:

1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

2. Institute of Biomaterials and Medical Devices, Southeast University, Suzhou 215163, China

3. Southeast University Shenzhen Research Institute, Shenzhen 518000, China

4. Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing, China

5. Jiangsu Simcere Pharmaceutical Co., Ltd, Nanjing 210042, China

6. Nantong Univ, Inst Reprod Med, Med Sch, Nantong 226001, China

7. Department of Health Medicine, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, China

Abstract

A nanostructured lateral flow immunoassay strip with Au@SiO2 SERS nanotags was constructed. This is the first time nanostructured T line and SERS-LFA has been combined, which has great potential for early non-invasive detection of AD biomarkers in blood.

Funder

Jiangsu Provincial Key Research and Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Chemistry (miscellaneous)

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