A dynamic matrix potentiates mesenchymal stromal cell paracrine function via an effective mechanical dose-Reference-Cited by-同舟云学术

A dynamic matrix potentiates mesenchymal stromal cell paracrine function via an effective mechanical dose

Published:2020 Issue:17 Volume:8 Page:4779-4791
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Lin Chuanchuan¹²³⁴⁵,Xu Kun¹²³⁴⁵,He Ye¹²³⁴⁵^ORCID,Tao Bailong¹²³⁴⁵,Yuan Zhang¹²³⁴⁵,Li Ke¹²³⁴⁵^ORCID,Li Xuemin⁶⁷³⁸⁵,Xia Zengzilu¹²³⁴⁵^ORCID,Cai Kaiyong¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Biorheological Science and Technology of Ministry of Education

2. College of Bioengineering

3. Chongqing University

4. Chongqing 400044

5. China

6. Innovation Drug Research Centre

7. School of Pharmaceutical Sciences

8. Chongqing 401331

Abstract

Compared to static conditions, MSCs in a dynamic matrix possess higher paracrine function as a result of collecting a mechanical dose through a cytoskeleton-YAP system.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM01012J

Reference51 articles.

1. Matrix Elasticity Directs Stem Cell Lineage Specification

2. Combining insoluble and soluble factors to steer stem cell fate