Copper(i)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones
Author:
Affiliation:
1. College of Chemistry
2. Green Catalysis Center
3. International Phosphorus Laboratory
4. International Joint Research Laboratory for Functional Organophosphorus Materials of Henan Province
5. Zhengzhou University
Abstract
A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3′-oxindole]s in good yields with high ee.
Funder
National Natural Science Foundation of China
Ministry of Industry and Information Technology of the People's Republic of China
China Postdoctoral Science Foundation
Zhengzhou University
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00546K
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2. Natural products in drug discovery
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