Membrane packing defects in synaptic vesicles recruit complexin and synuclein-Reference-Cited by-同舟云学术

Membrane packing defects in synaptic vesicles recruit complexin and synuclein

Published:2021 Issue:3 Volume:23 Page:2117-2125
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Liu Jie¹²³,Bu Bing⁴⁵³^ORCID,Crowe Michael⁶⁷⁸,Li Dechang⁹¹⁰³^ORCID,Diao Jiajie⁶⁷⁸^ORCID,Ji Baohua⁹¹⁰³^ORCID

Affiliation:

1. Biomechanics and Biomaterials Laboratory, Department of Applied Mechanics, Beijing Institute of Technology

2. Beijing 100081

3. China

4. Institute of Biomedical Engineering and Health Sciences, Changzhou University

5. Changzhou

6. Department of Cancer Biology, University of Cincinnati College of Medicine

7. Cincinnati

8. USA

9. Institute of Applied Mechanics, Department of Engineering Mechanics, Zhejiang University

10. Hangzhou 310027

Abstract

Higher membrane curvature is associated with more lipid packing defects. The preferential association of complexin and synuclein to synaptic vesicles is attributed to the preferential interaction between the protein and the packing defects.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D0CP03546G

Reference66 articles.

1. Membrane fusion

2. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

3. SNAREpins: Minimal Machinery for Membrane Fusion

4. Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

5. Complexins: Cytosolic proteins that regulate SNAP receptor function

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