RE3Sb3Zn2O14 (RE = La, Pr, Nd, Sm, Eu, Gd) is a series of novel pyrochlore-related materials with 2D Kagome lattices formed by RE3+ and Sb5+. The rare earth is the only magnetic ion in the structure; this family is therefore an archetype for exploring magnetic frustration on a 2D Kagome lattice.