A step-economic and one-pot access to chiral Cα-tetrasubstituted α-amino acid derivatives via a bicyclic imidazole-catalyzed direct enantioselective C-acylation-Reference-Cited by-同舟云学术

A step-economic and one-pot access to chiral Cα-tetrasubstituted α-amino acid derivatives via a bicyclic imidazole-catalyzed direct enantioselective C-acylation

Published:2020 Issue:18 Volume:11 Page:4801-4807
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Mo¹²³⁴⁵,Zhou Muxing⁶⁴⁵⁷,Zhang Lu⁶⁴⁵⁷,Zhang Zhenfeng⁶⁴⁵⁷^ORCID,Zhang Wanbin¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs

2. School of Chemistry and Chemical Engineering

3. Frontiers Science Center for Transformative Molecules

4. Shanghai Jiao Tong University

5. Shanghai 200240

6. School of Pharmacy

7. China

Abstract

The first four-step sequential reaction for the synthesis of C^α-tetrasubstituted chiral α-amino acid derivatives via auto-tandem catalysis has been developed.

Funder

E-Institutes of Shanghai Municipal Education Commission

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC00808G

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