Intra-articular TSG-6 delivery from heparin-based microparticles reduces cartilage damage in a rat model of osteoarthritis-Reference-Cited by-同舟云学术

Intra-articular TSG-6 delivery from heparin-based microparticles reduces cartilage damage in a rat model of osteoarthritis

Published:2018 Issue:5 Volume:6 Page:1159-1167
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Tellier Liane E.¹²³⁴,Treviño Elda A.¹²³⁴,Brimeyer Alexandra L.¹²³⁴,Reece David S.¹²³⁴,Willett Nick J.¹²³⁴⁵,Guldberg Robert E.⁶⁷³⁴⁸,Temenoff Johnna S.¹²³⁴⁶

Affiliation:

1. W. H. Coulter Department of Biomedical Engineering

2. Georgia Institute of Technology and Emory University

3. Atlanta

4. USA

5. Department of Orthopedics

6. Petit Institute for Bioengineering and Bioscience

7. Georgia Institute of Technology

8. Department of Mechanical Engineering

Abstract

As a potential treatment for osteoarthritis (OA), we have developed hydrolytically degradable heparin-based biomaterials for the intra-articular delivery of tumor necrosis factor-alpha stimulated gene-6 (TSG-6).

Funder

National Science Foundation

Georgia Institute of Technology

Emory University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/BM/C8BM00010G

Reference53 articles.

1. Intraarticular drug delivery in osteoarthritis☆