Acetyl shikonin induces IL-12, nitric oxide and ROS to kill intracellular parasite Leishmania donovani in infected hosts-Reference-Cited by-同舟云学术

Acetyl shikonin induces IL-12, nitric oxide and ROS to kill intracellular parasite Leishmania donovani in infected hosts

Published:2016 Issue:66 Volume:6 Page:61777-61783
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Charan Raja Mamilla R.¹²³⁴⁵,Srinivasan Sujatha¹²³⁴⁵,Subramaniam Shankar⁶⁷³⁴⁵,Rajendran Narendran⁶⁷³⁴⁵,Sivasubramanian Aravind⁶⁷³⁴⁵^ORCID,Kar Mahapatra Santanu¹²³⁴⁵

Affiliation:

1. Medicinal Chemistry and Immunology Laboratory

2. Department of Biotechnology

3. School of Chemical and Biotechnology

4. SASTRA University

5. Thanjavur–613 401

6. Natural Products Chemistry Laboratory

7. Department of Chemistry

Abstract

Acetyl shikonin (AS), a naphthoquinone isolated from Arnebia nobilis, was tested against visceral leishmaniasis in this study, revealing that AS provides a chemo-immunotherapeutic strategy against visceral leishmaniasis.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA11510A

Reference48 articles.

1. Visceral leishmaniasis: Report of a WHO bi-regional consultation Addis Ababa, Ethiopia, 2015

2. Unresponsiveness to Glucantime Treatment in Iranian Cutaneous Leishmaniasis due to Drug-Resistant Leishmania tropica Parasites

3. The Relationship between Leishmaniasis and AIDS: the Second 10 Years