In situ real time monitoring of emulsification and homogenization processes for vaccine adjuvants-Reference-Cited by-同舟云学术

In situ real time monitoring of emulsification and homogenization processes for vaccine adjuvants

Published:2022 Issue:3 Volume:147 Page:378-386
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Ralbovsky Nicole M.¹^ORCID,Soukup Randal J.²,Lomont Justin P.¹,Lauro Mackenzie L.¹^ORCID,Gulasarian Amanda²,Saha-Shah Anumita¹,Winters Michael A.²,Richardson Douglas D.¹,Wang Sheng-Ching²,Mangion Ian¹,Smith Joseph P.¹^ORCID

Affiliation:

1. Analytical Research & Development, MRL, Merck & Co., Inc., West Point, PA 19486, USA

2. Process Research & Development, MRL, Merck & Co., Inc., West Point, PA, 19486, USA

Abstract

Process analytical technology was used to monitor formation of a stable emulsion product, with results providing improved understanding of emulsion-based vaccine adjuvant formation processes.

Funder

Merck Sharp and Dohme

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AN/D1AN01797G

Reference35 articles.

1. Towards an understanding of the adjuvant action of aluminium

2. An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

3. Nanoemulsion: Concepts, development and applications in drug delivery