Efficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activities

Author:

Touj Nedra1234,Al-Ayed Abdullah S.56789,Sauthier Mathieu1011121314,Mansour Lamjed56789,Harrath Abdel Halim56789,Al-Tamimi Jamil56789,Özdemir Ismail1516171819,Yaşar Sedat1516171819,Hamdi Naceur12345ORCID

Affiliation:

1. Research Laboratory of Environmental Sciences and Technologies (LR16ES09)

2. Higher Institute of Environmental Sciences and Technology

3. University of Carthage

4. Tunisia

5. Chemistry Department

6. College of Science and Arts

7. Qassim University

8. Al-Rass

9. Kingdom of Saudi Arabia

10. Ecole Nationale Supérieure de Chimie de Lille

11. Unité de Catalyse et Chimie du Solide

12. UMR CNRS 8181

13. USTL

14. France

15. İnönü University

16. Faculty of Science and Art

17. Department of Chemistry

18. Malatya

19. Turkey

Abstract

The in situ prepared four component system Pd(OAc)2, 1,3-dialkylbenzimidazolium halides 2a–i and 4a–i, K2CO3 under CO atmosphere catalyses carbonylative cross-coupling reaction of 2-bromopyridine with various boronic acids to yield unsymmetrical arylpyridine ketones.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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