Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo
Author:
Affiliation:
1. The Department of Surgery
2. University of Melbourne
3. Austin Health
4. , Australia
5. Department of Paediatrics
6. Murdoch Children's Research Institute
7. Royal Children's Hospital
Abstract
Over-expression of growth factors can contribute to the development and progression of cancer, and gastrins in particular have been implicated in accelerating the development of gastrointestinal cancers.
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MT/C5MT00147A
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4. Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)
5. Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter
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