Preparation and application of quick hemostatic gauze based on biomimetic mineralized thrombin

Author:

Shi Yuting12,Ding Xiaoquan3ORCID,Cao Yufei1,Zhou Haicun4,Yu Wenwen4,Liu Mingsheng1,Yin Juanjuan1,Liu Hongbin4,Wang Jingjing2,Huang Congshu2,Gong Chenliang1ORCID,Wei Hua1ORCID,Zhao Guanghui1ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry, Institute of Biochemical Engineering & Environmental Technology, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China

2. State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI), Xiamen, 361101, P. R. China

3. Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, P. R. China

4. The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, P. R. China

Abstract

This work aims to prepare ion/thrombin hybrid microflowers and thrombin/MOF by means of different biomineralization methods to improve the instability, bioavailability and poor storage stability of thrombin.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Gansu Province

Natural Science Foundation of Qinghai

State Key Laboratory For Marine Corrosion and Protection, Luoyang Ship Material Research Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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