6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria-Reference-Cited by-同舟云学术

6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria

Published:2022 Issue:5 Volume:3 Page:551-560
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Meijlink Michael A.¹,Chua Yu Cheng²^ORCID,Chan Susanna T. S.¹,Anderson Regan J.¹^ORCID,Rosenberg Matthew W.¹^ORCID,Cozijnsen Anton³,Mollard Vanessa³,McFadden Geoffrey I.³,Draper Sarah L.¹^ORCID,Holz Lauren E.²,Hermans Ian F.⁴⁵,Heath William R.²^ORCID,Painter Gavin F.¹⁵^ORCID,Compton Benjamin J.¹^ORCID

Affiliation:

1. Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand

2. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia

3. School of BioSciences, University of Melbourntie, Parkville, VIC, Australia

4. Malaghan Institute of Medical Research, Wellington, New Zealand

5. Avalia Immunotherapies Limited, Lower Hutt, New Zealand

Abstract

Candidate vaccines comprised of peptide antigen conjugated to 6″-modified α-GalCer analogues generate potent hepatic TRMresponses in mice with a single dose inducing protective immunity against malaria in aPlasmodiumsporozoite challenge model.

Funder

Ministry of Business, Innovation and Employment

Health Research Council of New Zealand

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00251A

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1. Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus