Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines-Reference-Cited by-同舟云学术

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines

Author:

Horwitz Samantha M.¹^ORCID,Blue Tamra C.¹,Ambarian Joseph A.¹^ORCID,Hoshino Shotaro²,Seyedsayamdost Mohammad R.²^ORCID,Davis Katherine M.¹^ORCID

Affiliation:

1. Department of Chemistry, Emory University, Atlanta, GA 30322, USA

2. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA

Abstract

We report the first structures of bacterial HAQs bound to their target DHODH and provide insights into mechanism of inhibition.

Funder

National Institute of General Medical Sciences

Japan Society for the Promotion of Science

Arnold and Mabel Beckman Foundation

National Cancer Institute

Office of Science

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

Reference34 articles.

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