Unveiling conformational dynamics changes of H-Ras induced by mutations based on accelerated molecular dynamics
Author:
Affiliation:
1. School of Science
2. Shandong Jiaotong University
3. Jinan 250357
4. China
5. Drug Discovery and Design Center
6. CAS Key Laboratory of Receptor Research
7. Shanghai Institute of Materia Medica
8. Chinese Academy of Sciences
9. Shanghai 201203
Abstract
The conformational transformation of two switches caused by mutations induces different free energy profiles of H-Ras.
Funder
National Basic Research Program of China
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2020/CP/D0CP03766D
Reference104 articles.
1. Small-molecule modulation of Ras signaling
2. The Guanine Nucleotide-Binding Switch in Three Dimensions
3. Ras Conformational Ensembles, Allostery, and Signaling
4. Structural Basis for Conformational Dynamics of GTP-bound Ras Protein
5. The many faces of Ras: recognition of small GTP-binding proteins
Cited by 35 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Conformational States of the GDP- and GTP-Bound HRAS Affected by A59E and K117R: An Exploration from Gaussian Accelerated Molecular Dynamics;Molecules;2024-01-30
2. The switch states of the GDP-bound HRAS affected by point mutations: a study from Gaussian accelerated molecular dynamics simulations and free energy landscapes;Journal of Biomolecular Structure and Dynamics;2023-05-22
3. Molecular Insights into the Improved Bioactivity of Interferon Conjugates Attached to a Helical Polyglutamate;Langmuir;2023-04-26
4. Impacts of Mutations in the P-Loop on Conformational Alterations of KRAS Investigated with Gaussian Accelerated Molecular Dynamics Simulations;Molecules;2023-03-23
5. Binding modes of GDP, GTP and GNP to NRAS deciphered by using Gaussian accelerated molecular dynamics simulations;SAR and QSAR in Environmental Research;2023-01-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3