Cytoprotective effects of imidazole-based [S1] and [S2]-donor ligands against mercury toxicity: a bioinorganic approach

Author:

Karri Ramesh123,Chalana Ashish123,Das Ranajit123,Rai Rakesh Kumar123,Roy Gouriprasanna123ORCID

Affiliation:

1. Department of Chemistry, School of Natural Sciences, Shiv Nadar University

2. Gautam Buddha Nagar

3. India

Abstract

[S2]-Donor ligands L2 and L3 showed remarkable ability to protect liver cell against HgCl2induced toxicity and the strength of their efficacy is in the order of L3 > L2 > L1. Interestingly, 60% decrease of ROS production was observed in liver cells co-treated with HgCl2and L3 in comparison to the cells treated with HgCl2only.

Funder

Science and Engineering Research Board

Shiv Nadar University

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

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