Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions
Author:
Affiliation:
1. Department of Applied Chemistry
2. Graduate School of Engineering
3. Kyushu University
4. Nishi-ku
5. Japan
6. Department of Chemical Engineering
7. Universiti Teknologi PETRONAS Bandar Seri Iskandar
8. 32610 Seri Iskandar
9. Malaysia
Abstract
We report a novel ionic liquid (IL)-mediated transcutaneous vaccine formulation consisting of a solid-in-oil nanodispersion of antigen coated with pharmaceutically accepted surfactants dispersed in IL-containing oil. The introduction of IL in the formulation significantly enhanced the skin permeability of ovalbumin, a model antigen.
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00378D
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