Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones-Reference-Cited by-同舟云学术

Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones

Published:2016 Issue:41 Volume:6 Page:34588-34599
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Raghav Neera¹²³⁴,Jangra Suman¹²³⁴,Kumar Ajay⁵⁶⁴,Bhattacharyya Shalmoli⁵⁶⁴,Wadhwa Deepak⁷⁸⁴,Sindhu Jayant⁹⁴

Affiliation:

1. Department of Chemistry

2. Kurukshetra University

3. Kurukshetra-136118

4. India

5. PGIMER

6. Chandigarh

7. Isharjyot Degree College

8. Pehowa

9. S.D. (P. G.) College Panipat

Abstract

A novel series of 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one derivatives synthesized and structure confirmed by X-ray crystallography have been evaluated as inhibitors to cathepsins B, H and L as well as cell proliferating agents.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA06480A

Reference47 articles.

1. Cathepsin B in osteoarthritis: zonal variation of enzyme activity in human femoral head cartilage.

2. Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage.

3. Cathepsins B, H and L activities in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects

4. Fucose-Containing Oligosaccharides from Human Milk from a Donor of Blood Group 0 LeaNonsecretor

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