Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers-Reference-Cited by-同舟云学术

Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers

Published:2016 Issue:20 Volume:14 Page:4718-4727
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hottin Audrey¹²³⁴⁵,Wright Daniel W.⁶⁷⁸,Moreno-Clavijo Elena⁹¹⁰¹¹¹²¹³,Moreno-Vargas Antonio J.⁹¹⁰¹¹¹²¹³,Davies Gideon J.⁶⁷⁸,Behr Jean-Bernard¹²³⁴⁵

Affiliation:

1. Université de Reims Champagne-Ardenne

2. Institut de Chimie Moléculaire de Reims

3. CNRS UMR 7312

4. UFR des Sciences Exactes et Naturelles

5. 51687 Reims Cedex 2

6. Structural Biology Laboratory Department of Chemistry

7. York YO10 5DD

8. UK

9. Departamento de Química Orgánica

10. Facultad de Química

11. Universidad de Sevilla

12. 41012 Sevilla

13. Spain

Abstract

The possible mechanisms of action of a dimeric fucosidase inhibitor are discussed through enzymatic assays of a series of analogues and crystallographic analysis of the enzyme-inhibitor complex.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00647G

Reference76 articles.

1. Glycan-dependent leukocyte adhesion and recruitment in inflammation

2. Pathogen-Host Protein-Carbohydrate Interactions as the Basis of Important Infections

3. Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

4. Galectins: A New Family of Regulators of Inflammation

5. Carbohydrate-Protein Interactions: Basis of Glycobiology

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