Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases-Reference-Cited by-同舟云学术

Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases

Published:2023 Issue:34 Volume:14 Page:9136-9144
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

van der Gracht Daniël¹,Rowland Rhianna J.²^ORCID,Roig-Zamboni Véronique³,Ferraz Maria J.¹,Louwerse Max¹^ORCID,Geurink Paul P.⁴^ORCID,Aerts Johannes M. F. G.¹^ORCID,Sulzenbacher Gerlind³^ORCID,Davies Gideon J.²^ORCID,Overkleeft Herman S.¹^ORCID,Artola Marta¹^ORCID

Affiliation:

1. Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

2. York Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, UK

3. Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille University, Marseille, France

4. Department of Cell and Chemical Biology, Leiden University Medical Centre, 2333 ZC Leiden, The Netherlands

Abstract

Parallel FluoPol-ABPP screenings on lysosomal β-glucosidase (GBA1) and α-glucosidase (GAA) revealed a N-9-phenanthrenyl-DNJ that inhibits GAA selectively and is an interesting hit for the development of chaperones for Pompe disease.

Funder

Royal Society

Biotechnology and Biological Sciences Research Council

French Infrastructure for Integrated Structural Biology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01021J

Reference32 articles.

1. Lysosomes as dynamic regulators of cell and organismal homeostasis

2. The rapidly evolving view of lysosomal storage diseases

3. Lysosomal storage diseases

4. Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions

5. Niemann-Pick disease type C

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Carbon/ruthenium hybrid nanozymes for efficient β-glucosidase sensing;Microchemical Journal;2024-09