High biocompatibility and improved osteogenic potential of amorphous calcium carbonate/vaterite

Author:

Tolba Emad1234,Müller Werner E. G.1234,Abd El-Hady Bothaina M.56789,Neufurth Meik1234,Wurm Frederik101134,Wang Shunfeng1234,Schröder Heinz C.1234,Wang Xiaohong1234

Affiliation:

1. ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry

2. University Medical Center of the Johannes Gutenberg University

3. D-55128 Mainz

4. Germany

5. Biomaterials Department

6. Inorganic Chemical Industries Division

7. National Research Center

8. Doki 11884

9. Egypt

10. Department of Physical Chemistry of Polymers

11. Max Planck Institute for Polymer Research

Abstract

Metastable amorphous calcium carbonate (ACC), formed as a precursor of crystalline carbonated apatite/hydroxyapatite in human bone, can be stabilized by inorganic polyphosphate. The resulting CaCO3/polyP, containing small amounts of vaterite, has osteogenic potential and potential application as a scaffold material for bone implants.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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