The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells-Reference-Cited by-同舟云学术

The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

Published:2015-09-10 Issue:6 Volume:4 Page:1439-1442
ISSN:2045-4538
Container-title:Toxicology Research
language:en
Short-container-title:

Author:

Tawari Patricia Erebi¹,Wang Zhipeng¹,Najlah Mohammad²,Tsang Chi Wai³,Kannappan Vinodh¹,Liu Peng¹,McConville Christopher⁴,He Bin⁵,Armesilla Angel L.¹,Wang Weiguang¹

Affiliation:

1. Research Institute in Healthcare Science, Faculty of Science & Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK. Fax: +44 (0)1902 322714; Tel: +44 (0)1902 322756

2. Medicine & Healthcare Science, Faculty of Medical Science, Anglia Ruskin University, UK

3. School of Chemistry, University of Birmingham, UK

4. School of Pharmacy, Faculty of Science & Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK

5. National Engineering Res Centre for Biomaterials, Sichuan University, China

Abstract

Abstract The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://academic.oup.com/toxres/article-pdf/4/6/1439/36632015/toxres_4_6_1439.pdf

Reference21 articles.

1. The Actions and Metabolic Fate of Disulfiram

2. Disulfiram Facilitates Intracellular Cu Uptake and Induces Apoptosis in Human Melanoma Cells

3. Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity

4. Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

5. Cu/Zn superoxide dismutase plays a role in angiogenesis

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