15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents-Reference-Cited by-同舟云学术

15N-Azides as practical and effective tags for developing long-lived hyperpolarized agents

Published:2021 Issue:42 Volume:12 Page:14309-14315
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bae Junu¹,Zhang Guannan¹,Park Hyejin¹,Warren Warren S.¹²³,Wang Qiu¹^ORCID

Affiliation:

1. Department of Chemistry, Duke University, Durham, North Carolina, 27708, USA

2. Department of Physics, Duke University, Durham, North Carolina, 27708, USA

3. Department of Radiology and Biomedical Engineering, Duke University, Durham, North Carolina, 27708, USA

Abstract

This work demonstrates that 15N-labeled azides are practical and effective tags for developing long-lived hyperpolarized MRI agents and can offer hyperpolarization lifetimes up to 9.8 min at 1 T and high polarization levels up to 11.6% in water.

Funder

National Science Foundation

Camille and Henry Dreyfus Foundation

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04647K

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