Diastereoselective synthesis of new zwitterionic bicyclic lactams, scaffolds for construction of 2-substituted-4-hydroxy piperidine and its pipecolic acid derivatives-Reference-Cited by-同舟云学术

Diastereoselective synthesis of new zwitterionic bicyclic lactams, scaffolds for construction of 2-substituted-4-hydroxy piperidine and its pipecolic acid derivatives

Published:2022 Issue:7 Volume:12 Page:4187-4190
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Reyes-Bravo Enrique¹,Gnecco Dino¹,Juárez Jorge R.¹^ORCID,Orea María L.¹,Bernès Sylvain²^ORCID,Aparicio David M.¹,Terán Joel L.¹^ORCID

Affiliation:

1. Centro de QuííInstituto de Cienciasmica, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Edif. IC-9 Complejo de Ciencias C.U., 72570 Puebla, Mexico

2. Instituto de Física, Benemérita Universidad Autónoma de Puebla, 1IF2(aka 110-B), Lab. 102, C.U., 72570 Puebla, Mexico

Abstract

The synthesis of new chiral highly functionalized zwitterionic bicyclic lactams starting from acyclic β-enaminoesters derived from (R)-(−)-2-phenylglycinol is described.

Funder

Consejo Nacional de Ciencia y Tecnología

Vicerrectoría de Investigación y Estudios de Posgrado, Benemérita Universidad Autónoma de Puebla

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA09298G

Reference35 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Controlled reduction of 5-alkyl-3-phenyl-2,3,5,6,7,8-hexahydro-oxazolo[3,2-a]pyridin-4-ylium iodide: enantioselective synthesis of (−)-dihydropinidine and (+)-indolizidine 167B

3. Syntheses of pyridin-4-ylium chirons: applications in a synthesis of (+)-coniine

4. A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams

5. Stereoselective α-amidoalkylation reactions of phenylglycinol-derived bicyclic lactams

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