Regio- and diastereoselective construction of conjugate oxindole derivatives enabled by delayed acyl transfer of pyridinium ylides

Author:

Zhang Mengchu1ORCID,Liu Gengxin1,Zhang Tianyuan1,Hong Kemiao1,Yang Xiangji1,Qiu Huang1ORCID,Hu Wenhao1

Affiliation:

1. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

Abstract

Herein, we design and develop a one-pot cascade strategy for the assembly of multi-substituted conjugate oxindole derivatives. This approach represents a new reaction mode for carbene gem-difunctionalization by delayed acyl transfer instead of delayed proton transfer.

Funder

Guangdong Key Laboratory for Big Data Analysis and Simulation of Public Opinion

Natural Science Foundation of Guangdong Province

Guangdong Province Introduction of Innovative R&D Team

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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