Avoiding pits on the energy landscape – alternative strategies for stabilizing nateglinide co-amorphous systems-Reference-Cited by-同舟云学术

Avoiding pits on the energy landscape – alternative strategies for stabilizing nateglinide co-amorphous systems

Published:2024 Issue:27 Volume:26 Page:3653-3664
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Silva Joana F. C.¹^ORCID,Jasiurkowska-Delaporte Małgorzata²^ORCID,Pereira Silva Pedro S.³,Silva Manuela Ramos³,Eusébio M. Ermelinda S.¹^ORCID,Rosado Mário T. S.¹^ORCID

Affiliation:

1. CQC-IMS, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal

2. Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, PL-31342 Kraków, Poland

3. CFisUC, Departamento de Física, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3000-370 Coimbra, Portugal

Abstract

Nateglinide is a prolific polymorph former. Cryo-milling and quench cooling were explored as alternatives to stabilize its co-amorphous systems with ranolazine and tryptophan, and their molecular dynamics of relaxation investigated.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CE/D4CE00195H

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